We report a case of primary cutaneous infection by the emerging fungus Aspergillus ustus in an immunosuppressed patient after a domestic accident. Aspergillus ustus is a mold that rarely infects humans; only 15 systemic cases have been reported. We report the first outbreak of invasive infection caused by A . Med Mycol. Jun;45(4) Clustering of invasive Aspergillus ustus eye infections in a tertiary care hospital: a molecular epidemiologic study of an.
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International Journal of Systematic and Evolutionary Microbiology.
More timely environmental sampling may have captured more environmental A. Suggested citation for this article: Fukuda T, Boeckh M, Carter RA Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning.
Such intensive monitoring may show similar outbreaks in other facilities. Support Center Support Center. A spot map depicting case-patient location and timeline relating location to time of diagnosis was created.
Aspergillus ustus Infections among Transplant Recipients
National Center for Biotechnology InformationU. The isolate from patient 3 was not viable on subculturing and, as such, was not available for molecular analysis.
We identified 2 clusters of A.
The second occurred from March to September 1 proven skin infection [likely sspergillus from lung] and 2 probable lung infections: Journal List Emerg Infect Dis v. Antifungal drug susceptibility testing of clinical isolates demonstrated relatively high MICs to all antifungal drugs tested Table 2. We report the first outbreak of invasive infection caused by A.
It is the main contaminant of cultivated soils but it occurs on other habitats:.
Am J Clin Pathol. Epidemiologic Investigation Estimating that patients were admitted for HSCT during the at-risk period, the aspegillus overall attack rate was 1. Active laboratory, environmental, and clinical-based surveillance for A. Like other members of the genus Aspergillusthe A. Thus, the source of A. Of note, the lung transplant patient appeared to be colonized with a strain of A. Table 2 Antifungal drug susceptibility testing of Aspergillus ustus isolates.
Clinical isolates exhibited decreased susceptibility to antifungal drugs, especially azoles. The spot map and time line showed that cases aspergiklus mainly along 2 corridors on 2 floors, 1 directly above the other, around the time of diagnosis. Environmental air sampling performed 2 months after the last case occurred in found no A. Retrieved from ” https: On CYA growth medium pH 5.
The Journal of Antibiotics. Bartizal Aspergillus, Odds FC Influences of methodological variables on susceptibility testing of caspofungin against Candida species and Aspergillus fumigatus. Sharp, demarcated white areas over dorsal hands and arms. Six patients with infections were identified; 3 infections each occurred in both and Author information Copyright and License information Disclaimer.
Drug exposure may select for colonization or infection with resistant isolates or facilitate acquired resistance within a colonizing strain.
Microscopically, the conidia are large 3. The hospital is a large tertiary care facility that houses patients with HSCT on the top 2 floors the northeast wings of the seventh and eighth floors. Guide to clinically significant ustjs.
Specifically, genomic rearrangement with recombination, which has been postulated to occur in several species of Aspergillusmay increase the variation observed between related strains We thank Estella Whimbey and Nancy Whittington for their help with acquiring information on hospital airflow and construction activity, Robin Olsen for performing the environmental air sampling, Chris Davis for database support, David Madtes and Pat McDowell for aspergillux bronchoscopic information, and S.
Aslergillus acid has since been shown to occur in other fungi, notably closely related Aspergilli such as A. Information on timing of construction activities and airflow information was obtained from hospital engineering and infection control personnel.
Mixtures were subjected to 3 cycles of freeze-thaw in liquid nitrogen, aspergilluz with vortexing with 0. Patient 3 was in the outpatient clinic at the time of diagnosis and is, therefore, not marked on this inpatient spot map. Disseminated aspergillosis caused by Aspergillus ustus in a patient following allogeneic peripheral stem cell transplantation. A source investigation of this mini outbreak was performed by environmental sampling, but no isolates of A.
Many reported cases have been either primary cutaneous disease or disseminated infection, however, aspergilluus cannot draw firm conclusions regarding the types of infections this organism causes because of the high likelihood of reporting bias. Construction, a well-known environmental risk factor for IA 36was ongoing outside the hospital during the time of these outbreaks.
Possible emission of a yellowish pigment. Curr Infect Dis Rep. Aspergillus ustus, antifungal drug resistance, emerging pathogen, outbreak, transplantation, research. Also, these analyses are limited by our lack of ustua concerning A.
Emerg Infect Dis [serial on the Internet]. Methods Case Identification and Environmental Surveillance Recognition of time-clustered cases in prompted us to do this retrospective study and epidemiologic investigation.
Recognition of invasive infections that occurred in 2 clusters of hematopoietic stem cell transplant HSCT recipients in our institution prompted us to perform a more thorough clinical investigation and environmental sampling to identify potential sources of acquisition.
Aspergillus Fungi described in